Romanian Society of Pharmaceutical Sciences
 

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EVALUATION OF ANTIMICROBIAL ACTIVITY OF SOME TYPES OF INCLUSION COMPLEXES OF ERYTHROMYCIN WITH β-CYCLODEXTRIN ON STAPHYLOCOCCUS AUREUS

ELEONORA MARIAN1*, MARIANA MURESAN2, TUNDE JURCA1, LAURA VICAS1

1University of Oradea, Medicine and Pharmacy Faculty, Department of Pharmacy, 29 Nicolae Jiga Str., 410028, Oradea, Romania
2 University of Oradea, Medicine and Pharmacy Faculty, Department of Preclinical Disciplines, 10 1 December Str., Oradea, Romania

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Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration. The purpose of this study was to evaluate the antimicrobial activity of the inclusion complexes of erytromycin with β -cyclodextrin synthesized by three methods: kneading, co-precipitation and freeze-drying. The inclusion compounds were synthesized using a molar ratio of erythromycin: β-cyclodextrin of 1:1. To determine the antimicrobial activity of erythromycin and its inclusion complexes, we used the disk diffusion method on Muller-Hinton medium and Staphylococcus aureus ATCC 25923 was used as quality control organisms. Our determinations showed that the tested complexes erythromycin- β – cyclodextrin had a strong antimicrobial activity.