Romanian Society of Pharmaceutical Sciences
 

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THE CORRELATIONS BETWEEN PLASMA LEPTIN AND THE CONCENTRATIONS OF PROINFLAMMATORY CYTOKINES IN PATIENTS WITH TYPE II DIABETES MELLITUS IN MAINTENANCE HEMODIALYSIS

ANGELA ANTONESCU1, OTILIA MICLE1*, SIMONA IOANA VICAŞ2, GABRIEL BAKO3, CAMELIA MRAZ1, LAURA VICAŞ4, MARIANA MUREŞAN1

1University of Oradea, Medicine and Pharmacy Faculty, Department of Preclinical Disciplines, Oradea, Romania
2 University of Oradea, Faculty of Environmental Protection, Oradea, Romania
3 University of Oradea, Medicine and Pharmacy Faculty, Department of Internal Medicine, Oradea, Romania
4 University of Oradea, Medicine and Pharmacy Faculty, Department of Pharmacy, Oradea, Romania

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The goal of the study was to asses the serum level of leptin and to establish if there is a relationship between leptin and proinflammatory cytokines in diabetic and nondiabetic patients submitted to chronic hemodialysis. The study included 20 type II diabetic patients and 15 non-diabetic patients in maintenance hemodialysis. A group of 30 healthy age-matched subjects were used as control. The serum levels of leptin and inflammatory cytokines were determined: IL-6 (Interleukin 6), IL-8 (Interleukin 8), TNF-α (Tumor necrosis factor) before and after hemodialysis. The diabetic female patients on dialysis have leptin, TNF-α, IL-8 levels significantly higher than in control group (p<0.0001). Leptin did not show critical differences in the three male groups (p>0.05). A negative correlation was detected only in diabetic female patients between serum ferritin and serum leptin (Pearson index -0.6062) and a positive correlation with BMI (Body mass index), (Pearson index 0.6657). Serum leptin levels in hemodialysed patients with type II diabetes mellitus do not differ significantly from those of hemodialysed non-diabetic patients.