Romanian Society of Pharmaceutical Sciences
 

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NEW MODIFIED RELEASE TABLETS WITH PENTOXIFYLLINE BASED ON LIPOPHILIC MATRIX. NOTE 2. STABILITY STUDY OF THE ACTIVE SUBSTANCE FROM THE PROPOSED FORMULATIONS

ELEONORA MIRCIA1*, SILVIA IMRE2, EMESE SIPOS3, VERONICA AVRIGEANU1, GABRIEL HANCU4, BARNA IANTOVICS5, TEODORA BALACI6

University of Medicine and Pharmacy Târgu-Mureş, Faculty of Pharmacy, Gh. Marinescu 38, 540139, Târgu-Mureş, Romania
1 Organic Chemistry Department
2 Drug Analysis Department
3 Pharmaceutical Technology Department
4 Pharmaceutical Chemistry Department
5 “Petru Maior” University, Faculty of Science and Letters, Department of Mathematics and Informatics, Târgu-Mureş, Romania
6 University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Pharmaceutical Technology Department, Bucharest, Romania

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The objective of this study was to test the stability of pentoxifylline in experimental formulations based on lipophilic matrix. In order to achieve this, we studied the influence of heat stress on the stability of the proposed formulations, by keeping the product samples at high temperatures and humidity, in a stability chamber, during periods lasting from one to six months, sampling at different periods of time and then analyzing the test samples. Experimental results show that all the proposed formulations can be considered stable.