Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS OF SOME 1,4-DISUBSTITUTED THIOSEMICARBAZIDES AS INTERMEDIATES FOR THE SYNTHESIS OF 1,3,4-THIADIAZOLE DERIVATIVES

TUNDE HORVATH1*, GEORGETA ŞERBAN1, STELA CUC2

1University of Oradea, Faculty of Medicine and Pharmacy, Pharmaceutical Chemistry Department, 29 Nicolae Jiga, 410028 Oradea, Romania
2 University of Waterloo, Department of Earth Sciences, Environmental Isotope Laboratory, Waterloo, Ontario, Canada

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The 4-phenyl-1-[α-acylamino-β-(p-X-phenyl)]acriloyl thiosemicarbazides 3a-h were synthesized using 2-R-4-(p-X-benzylidene)-oxazol-5-ones 1a-h as starting materials. The reaction of compounds 1a-h with hydrazine hydrate led to the formation of acid hydrazides 2a-h. The thiosemicarbazide derivatives 3a-h were obtained by nucleophilic addition of corresponding acid hydrazides 2a-h to phenylisothiocyanate. The newly synthesized compounds structures were elucidated by spectral data and elemental analysis.