Romanian Society of Pharmaceutical Sciences
 

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IMPROVED ACTIVITY OF AMINOGLYCOSIDES ENTRAPPED IN SILICA NETWORKS AGAINST MICROBIAL STRAINS ISOLATED FROM OTOLARYNGOLOGICAL INFECTIONS

ION ANGHEL1,2*, ALEXANDRU MIHAI GRUMEZESCU3, ALINA MARIA HOLBAN4, IRINA GHEORGHE4, MIHAELA VLAD3, GEORGIANA ALINA ANGHEL5, PAUL CATALIN BALAURE3, CARMEN MARIANA CHIFIRIUC4, IOANA MIHAIELA CIUCA6

1.University of Medicine Carol Davila Bucharest, Romania
2 .Doctor Anghel Medical Center, Theodor Sperantia Street, Bucharest, Romania
3 .Politehnica University of Bucharest, Faculty of Applied Chemistry and Materials Science, Bucharest, Romania
4 .University of Bucharest, Faculty of Biology, Microbiology Immunology Department, Bucharest, Romania
5 .ENT (Otorhinolarynqology) Clinic, Coltea Hospital, Bucharest, Romania
6 .Pediatrics Department, Victor Babes University of Medicine and Pharmacy Timisoara, Romania

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The purpose of this study was to investigate the efficiency of natural and synthetic zeolites as carriers for aminoglycoside antibiotics,by using an adapted diffusion method and microbial strains isolated from otolaryngological infections. The results showed that the natural and synthetic zeolites proved to be excellent carriers for aminoglycosides, exhibiting a strong potentiator effect on the activity of kanamycin and streptomycin, especially against the Gram-positive bacterial strains, as demonstrated by the drastic increase of the growth inhibition zone diameters induced by the antibiotics entrapped in the silica networks. These results are demonstrating the utility of silica networks in the pharmaceutical industry for the identification of new ways to improve the bioavailability and dissolution of the currently used antibiotics.