Romanian Society of Pharmaceutical Sciences
 

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EFFECTS OF A TOPICAL PREPARATION CONTAINING SAMBUCI FOLIUM EXTRACT IN EXPERIMENTAL MODEL OF THERMAL SKIN BURNS ON RATS

GEORGE DAN MOGOŞANU1*, FLORINA CARMEN POPESCU2, CRISTINA JANA BUSUIOC2, OLTIN TIBERIU POP2, LAURENȚIU MOGOANTĂ2, HORIA PÂRVĂNESCU3, GABRIELA RĂU4, IOAN LASCĂR5

1.Department of Pharmacognosy and Phytotherapy
2 .Research Centre for Microscopic Morphology and Immunology
3 .Department of Plastic Surgery and Reconstructive Microsurgery
4 .Department of Organic Chemistry, Medicinal Chemistry University of Medicine and Pharmacy of Craiova, 2–4 Petru Rareş Street, 200349 Craiova, Romania
5 .Department of Plastic Surgery and Reconstructive Microsurgery, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, Sector 1, 020022 Bucharest, Romania

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The astringent, anti-inflammatory, antiseptic and cicatrizing effect of a coldcream containing Sambuci folium soft extract was established in experimental model of thermal skin burns, in Wistar rats. Animals in the first group, treated with cold-cream containing 10% vegetal extract, had a favourable evolution, the wound healing being almost complete after 21 days. The reference group, treated with 1% silver sulfadiazine cream, and the control group, treated with cold-cream base, showed a delay of wound healing, the epithelisation after 21 days being incomplete.