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STUDY ON THIAMPHENICOL – INDUCED SIDE EFFECTS IN HAMSTERS

MARIA CRIVINEANU¹, MANUELLA MILITARU¹, DENISA IOANA UDEANU², VALENTIN NICORESCU^1*, CAMELIA PAPUC¹, CORINA ANA IONIȚĂ², ELENA ROTARU¹

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The present study investigated the possible adverse effects of thiamphenicol in hamsters following the administration of therapeutic doses. Thiamphenicol was administered by intramuscular injection at a dose rate of 35 mg/kg body weight once daily for 7 days. Functional changes of bone marrow, liver and kidney were monitored; bone marrow cytology and histopathology of the liver, kidneys and heart were performed. Enzymatic markers of hepatic cell damage were slightly increased in the treatment groups. Urea and creatinine concentrations were higher in thiamphenicol-treated hamsters than in the control group, suggesting an alteration in renal function. Haematology parameters were altered in thiamphenicol-treated hamsters and bone marrow smears showed slight bone marrow depression affecting all haematopoietic cell lines. Following histopathological investigations, no changes in liver morphology could be observed. Isolated degenerative changes were observed in the proximal convoluted tubule epithelium, without loss of integrity or changes in renal architecture. Myocardial arteriole and capillary stasis and incipient haemolysis were observed as well as alterations in longitudinally sectioned myocardiocytes.