Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 4/2015

ARYLALIPHATIC AMINOALCOHOL DERIVATIVE KVM-194 AFFECTS E. COLI LIPOPOLYSACCHARIDE COMPOSITION

MARIA DRONOVA1*, NINA VRYNCHANU1, LYUDMILA VARBANETS2, YURI KOROTKIY3, OKSANA BROVARSKA2

1.”Institute of Pharmacology and Toxicology of NAMS of Ukraine”, Kiev, Ukraine
2 .”D.K. Zabolotny Institute of Microbiology and Virology of NAS of Ukraine”, Kiev, Ukraine
3 .”Institute of organic chemistry of NAS of Ukraine”, Kiev, Ukraine

Download Full Article PDF

The newly synthesized compound KVM-194, a derivative of aryl-aliphatic amino alcohols, possesses inhibitory activity against a broad spectrum of pathogens. The aim of the present study was to investigate the effect of the novel compound KVM-194 on the content and composition of Escherichia coli lipopolysaccharide. The obtained data suggest that KVM-194, in the sub-inhibitory concentration, changes the fatty acid and monosaccharide composition of lipopolysaccharide. These alterations may lead to changes in the structure, properties of the outer membrane, cell viability and its susceptibility to antibiotics.