Romanian Society of Pharmaceutical Sciences
 

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ANTIMICROBIAL AND SYNERGISTIC ACTIVITY OF SOME WHOLE AND SELECTIVE EPILOBIUM HIRSUTUM L. (GREAT WILLOWHERB) EXTRACTS TESTED ON STANDARD AND WILD STAPHYLOCOCCUS AUREUS STRAINS

LUCIA PIRVU1, VALENTIN NICORESCU2*, CRISTINA HLEVCA1, DENISA IOANA UDEANU3, ISABELA NICORESCU4

1.National Institute for Chemical Pharmaceutical R&D (INCDCF), Vitan 112, 031299, Bucharest, Romania
2 .University of Agronomic Sciences and Veterinary Medicine of Bucharest, Faculty of Veterinary Medicine, Splaiul Independentei 105, 050097, Bucharest, Romania
3 .University of Medicine and Pharmacy “Carol Davila”, Bucharest, Faculty of Pharmacy, Department of Clinical Laboratory and Food Safety, Traian Vuia 6, 020956, Bucharest, Romania
4 .Institute of Hygiene and Veterinary Public Health, Campul Mosilor 5, 021201, Bucharest, Romania

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This work aimed to establish Epilobium hirsutum L. (Onagraceae family) aerial part whole and selective extracts antimicrobial activity and possible synergism with some antibiotics (Gentamicin, Tetracycline, Ampicillin, Nalidixic acid and Ciprofloxacin) tested on standard and wild methicillin–resistant Staphylococcus aureus (MRSA) strains; the vegetal extracts had identical total phenols content, 5 mg gallic acid (GAE) equivalents 1 mL extract respectively. Thus, there were evidenced stimulatory effects between great willowherb extracts and Ampicillin; statistically significant differences were also obtained for the combination with Gentamicin and Ciprofloxacin, in these cases being recorded smaller inhibition zones compared to those of the antibiotics used alone (inhibitory effects).