Romanian Society of Pharmaceutical Sciences
 

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STUDY OF SYNERGIC EFFECT BETWEEN SOME METAL IONS AND ADRENALINE ON HUMAN BLOOD PLATELETS AGGREGATION

ALICE PIPEREA-ŞIANU1, IULIAN SÎRBU1*, ERAND MATI1 DAN PIPEREA-ŞIANU2, CONSTANTIN MIRCIOIU1

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Traian Vuia Street, No 6, 020956, Bucharest, Romania
2 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Dental Medicine, Calea Plevnei Street, No 19, 010221, Bucharest, Romania

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The paper presents the evaluation of effects of zinc, aluminium and copper ions in normal or toxic concentrations on the in vitro adrenaline induced platelet aggregation. Aggregation was studied according to a modified spectrophotometric method of Born using a Helena Laboratories Pack4 Aggregometer, in the platelet rich plasma. The curves were compared using as parameters the area under curve, maximum aggregation and aggregation rates. The effects of ions in the presence of adrenaline were, at least qualitatively, similar: an increase of aggregation face to single adrenaline induced aggregation due to decreasing of electrophoretic potential. The mechanism of synergism between ionic metals and adrenaline couldn’t be explained satisfactory. Nor in thermodynamic, nor in kinetic, nor in biochemical theories was possible to predict quantitatively the aggregation. Whatever the mechanism, the effects, even in case of high concentrations, were not high and had no clinical nor toxicological significance.