Romanian Society of Pharmaceutical Sciences
 

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CHITOSAN MICROPARTICLES LOADED WITH ANTIDIABETIC DRUGS – PREPARATION AND CHARACTERIZATION

IUSTINA AVRAM1, FLORENTINA GIANINA LUPAŞCU1, LUMINIŢA CONFEDERAT1, SANDRA MĂDĂLINA CONSTANTIN1, CRISTINEL IONEL STAN2*, LENUŢA PROFIRE1

1.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, România
2 .Department of Morphofunctional Science, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, România

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The objective of this study was to develop new binary polymeric systems based on chitosan in order to achieve an improvement of the pharmacokinetic and pharmacological profile of the two most used oral antidiabetic drugs - metformin and glibenclamide. The presence of the antidiabetic drugs in the polymer matrix was proved using IR spectroscopy. The optimized formulations were studied in terms of morphology, particle size, swelling degree and loading efficiency. The binary polymeric formulations (chitosan-metformin-glibenclamide) were characterized by the swelling degree and loading efficiency, higher than the unitary polymeric systems (chitosan-metformin and chitosan-glibenclamide). The highest loading efficiency was shown by the chitosan-metformin-glibenclamide formulation in 1:0.5:0.5 ratio (w/w/w).