Romanian Society of Pharmaceutical Sciences
 

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IN VITRO ASSESSMENTS OF POTENTIAL TOPICAL APPLICATION FOR ORGANOMETALLIC COMPLEXES OF COPPER WITH OXICAMS

CONSTANTIN-PETRU TUDOSĂ1, DUMITRU LUPULIASA2, SULTANA NIȚĂ3, MIRELA ADRIANA MITU2*, LUCIAN HÎNCU1, FLAVIAN ȘTEFAN RĂDULESCU1, DALIA SIMONA MIRON4

1Department of Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy, “Carol Davila” University of
Medicine and Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania
2 Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Carol Davila” University of
Medicine and Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania
3 National Institute for Chemical Pharmaceutical Research and Development, 112 Calea Vitan Street, Bucharest, Romania
4 Department of Pharmaceutical Physics and Informatics, Faculty of Pharmacy, “Carol Davila” University of Medicine and
Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania

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The paper presents the assessment of the solubility, distribution coefficient and in vitro release from liquid and semisolid vehicles for organometallic complexes of copper with oxicam ligands. Aqueous buffers systems with physiological pH and biorelevant organic solvents such as n-octanol and isopropyl-myristate were used in developing simple experimental procedures. The substances were described as model entities for increased hydrophobicity and the results were discussed in terms of the utility and limitations of these methodologies for screening the feasibility of delivery across the skin.