Romanian Society of Pharmaceutical Sciences
 

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DRUG ALLERGIES DUE TO IgE SENSITIZATION TO α-GAL

FLORIN-DAN POPESCU 1, OANA MARIANA CRISTEA 2*, FLORIANA-ELVIRA IONICĂ 3, MARIANA VIERU 1

1.Department of Allergology,“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 .Department of Microbiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
3 .Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania

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Serum specific IgE antibodies for non-primate mammalian carbohydrate galactose-α-1,3-galactose (α-Gal) are associated to α-Gal syndrome: delayed allergy to red meat manifested as anaphylaxis, angioedema or urticaria after ingestion of beef, pig or lamb meat, immediate-onset anaphylaxis at first parenteral exposure to drugs significantly containing α-Gal. IgE-mediated drug allergy in the α-Gal syndrome was reported for some therapeutic monoclonal antibodies, such as cetuximab, snake antivenom, and varicella-zoster vaccine, but there are risks also for colloid plasma volume substitutes, vaccines containing gelatine of porcine/bovine animal origin as an excipient, and drugs with porcine pancreatin or bovine-origin magnesium stearate.