Romanian Society of Pharmaceutical Sciences
 

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THE EFFICACY OF A PHYTOESTROGEN-RICH CHINESE MEDICINE ON SENILE OSTEOPOROSIS

NING GUO 1, BINGLIANG LI 2, XIAORUI JIANG 3*

1.Training Center, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, China
2 .Joint Surgery Department, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, China
3 .Orthopedics Department, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China a

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The aim of this study was to explore the potential therapeutic effect of a phytoestrogen-rich Chinese phytoterapeutics on senile osteoporosis. Sixty elderly osteoporosis patients admitted to Affiliated Hospital of Jining Medical University, Jining, Shandong, China from March 2016 to June 2017 were randomly divided into an experimental group (group A) and a control group (group B). Both groups received one tablet of 1.5 g calcium carbonate (ie 600 mg Ca2+ per tablet) plus 400 UI vitamin D3 per day, while group A also received Xianling Gubao capsules in the dose of three tablets twice a day. Before and after twelve weeks of administration, the changes of bone mineral density (BMD), serum calcium, serum phosphorus, alkaline phosphatase (AKP) and bone gla protein (BGP) levels were measured. There were no significant differences in BMD, serum calcium, serum phosphorus and AKP before treatment between group A and B (p > 0.05). After treatment, BMD and serum calcium increased, while serum phosphorus and AKP decreased significantly (p < 0.05). Compared with group B, the changes of each biomarker in group A were significantly improved after the treatment compared with group B (p < 0.05). Phytoestrogen-rich Chinese phytoterapeutic increased BMD and the level of blood calcium, decreased the level of blood phosphorus and AKP and showed to be a good natural adjuvant in the treatment of senile osteoporosis.