Romanian Society of Pharmaceutical Sciences

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URINARY TRACT INFECTIONS IN A ROMANIAN POPULATION: ANTIMICROBIAL RESISTANCE OF UROPATHOGENS – A MULTIREGIONAL STUDY

AUREL RUSU 1#, AIDA PETCA 2#, CRISTIAN MAREȘ 3#, RĂZVAN-COSMIN PETCA 3*, RĂZVAN-IONUȚ POPESCU 3, SILVIUS NEGOIȚĂ 4, RĂZVAN-ALEXANDRU DĂNĂU 3, CĂLIN BOGDAN CHIBELEAN 5, VIOREL JINGA 3

1Department of Urology, Vaslui Emergency County Hospital, Vaslui, Romania
2Department of Obstetrics and Gynecology, Elias Emergency Hospital,"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
3Department of Urology," Prof. Dr. Th. Burghele" Clinical Hospital,"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
4Department of Anesthesiology and Critical Care, Elias University Hospital,"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
5Department of Urology, Mureș County Hospital, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu-Mures, Târgu-Mureș, Romania

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Urinary Tract Infections (UTIs) are a serious public health problem determined by a large variety of microorganisms; the leading uropathogen is represented by Escherichia coli, followed by Klebsiella spp., Proteus spp., and Pseudomonas spp. as major Gram-negative bacteria. Enterococcus spp. and Staphylococcus spp. are the most frequent Gram-positive pathogens involved. The presented study aimed to corroborate results from four tertiary hospitals in three different regions of Romania. Analysing 15,907 urine probes, of which 2,842 (17.86%) met the inclusion criteria, for discovering the uropathogen involved in the dynamics of UTIs, desiring to determine the resistance and sensitivity patterns for each pathogen presented, in a comparative approach. Escherichia coli was the leading pathogen 1629 (57.31%), presenting the highest resistance to levofloxacin R = 20.62% and amoxicillin - clavulanic acid R = 18.17%; the second most frequent bacteria were Klebsiella spp. 530 (18.64%), with major resistance to amoxicillin-clavulanic ac. R = 45.66% and ceftazidime R = 29.05%. Enterococcus spp. was the most common Gram-positive strain 340 (11.96%), presenting important resistance to levofloxacin R = 32.35% and penicillin R = 25.29%. Current guidelines recommend adjusting treatment to local data in the management of UTIs; thus, this study involving all three major regions of Romania represents a pivotal point in providing an appropriate recommendation for every health professional.