Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 1/2023

URINARY TRACT INFECTIONS IN A ROMANIAN POPULATION: ANTIMICROBIAL RESISTANCE OF UROPATHOGENS – A MULTIREGIONAL STUDY

AUREL RUSU 1#, AIDA PETCA 2#, CRISTIAN MAREȘ 3#, RĂZVAN-COSMIN PETCA 3*, RĂZVAN-IONUȚ POPESCU 3, SILVIUS NEGOIȚĂ 4, RĂZVAN-ALEXANDRU DĂNĂU 3, CĂLIN BOGDAN CHIBELEAN 5, VIOREL JINGA 3

1Department of Urology, Vaslui Emergency County Hospital, Vaslui, Romania
2 Department of Obstetrics and Gynecology, Elias Emergency Hospital,"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
3 Department of Urology," Prof. Dr. Th. Burghele" Clinical Hospital,"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
4 Department of Anesthesiology and Critical Care, Elias University Hospital,"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
5 Department of Urology, Mureș County Hospital, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu-Mures, Târgu-Mureș, Romania

Download Full Article PDF

Urinary Tract Infections (UTIs) are a serious public health problem determined by a large variety of microorganisms; the leading uropathogen is represented by Escherichia coli, followed by Klebsiella spp., Proteus spp., and Pseudomonas spp. as major Gram-negative bacteria. Enterococcus spp. and Staphylococcus spp. are the most frequent Gram-positive pathogens involved. The presented study aimed to corroborate results from four tertiary hospitals in three different regions of Romania. Analysing 15,907 urine probes, of which 2,842 (17.86%) met the inclusion criteria, for discovering the uropathogen involved in the dynamics of UTIs, desiring to determine the resistance and sensitivity patterns for each pathogen presented, in a comparative approach. Escherichia coli was the leading pathogen 1629 (57.31%), presenting the highest resistance to levofloxacin R = 20.62% and amoxicillin - clavulanic acid R = 18.17%; the second most frequent bacteria were Klebsiella spp. 530 (18.64%), with major resistance to amoxicillin-clavulanic ac. R = 45.66% and ceftazidime R = 29.05%. Enterococcus spp. was the most common Gram-positive strain 340 (11.96%), presenting important resistance to levofloxacin R = 32.35% and penicillin R = 25.29%. Current guidelines recommend adjusting treatment to local data in the management of UTIs; thus, this study involving all three major regions of Romania represents a pivotal point in providing an appropriate recommendation for every health professional.