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UPDATES IN THE ASSESMENT OF RISK FACTORS IN CLOSTRIDIUM DIFFICILE INFECTION IN PATIENTS WITH INFECTIOUS DISEASES

MIHAELA CĂTĂLINA LUCA ^1#, FLORIN ROȘU ^1#, MIHNEA HURMUZACHE ^1#, ANDREI ȘTEFAN LUCA ^2#, DANIELA LECA ^1#, LUMINIȚA SMARANDA IANCU ^2#*, LĂCRĂMIOARA OCHIUZ ^3#

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Infection with Clostridium difficile has become increasingly more frequent in recent years, being currently one of the most common aetiology of diarrheal disease. The aim of our work was to broaden the current knowledge of the Clostridium difficile digestive infections in patients admitted to the Infectious Diseases Hospital from Iasi City, Romania. We have studied 166 patients with Clostridium difficile enterolactis, hospitalized between 01.01.2014 - 31.03 2015. We have found an increasing trend in the number of cases between December 2014 and March 2015, particularly among immunocompromised patients, 48% of cases occurred in patients with previous surgery area and 57% came from medical services. Investigation of the used groups of antibiotics revealed that the highest risk is the use of fluoroquinolones, followed by cephalosporins. Relapses were found in 28.67% cases, and treatment was performed with Metronidazole (66.26%), Vancomycin (5.42%) and Vancomycin + Metronidazole (28.31%). Analysis of cases is a warning on unjustified and irrational use of antibiotics and the danger of nosocomial infections.