Romanian Society of Pharmaceutical Sciences
 

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TOPICAL DELIVERY SYSTEM OF LIPOSOMALLY ENCAPSULATED VOLATILE OIL OF ANETHUM GRAVEOLENS

ALINA ORTAN1, MARIANA FERDES1, STELIANA RODINO2, CRISTINA DINU PIRVU3*, DOINA DRAGANESCU3

1University Politehnica of Bucharest, Splaiul Independentei no. 313, sector 6, Bucharest, Romania.
2National Institute of Research and Development for Biological Sciences, Splaiul Independentei, 296, P.O. Box 17-16, Bucharest, Romania
3Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, Traian Vuia 6, Bucharest, Romania

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An essential step in the characterization of liposomal systems as drug vectors is one that analyzes the release rate of incorporated substances. In vitro release tests are used not only to characterize various formulations of therapeutic use, but also to predict their in vivo behavior. The objective of this work was to formulate and in vitro characterize hydrogels containing liposomal suspension of Anethum graveolens volatile oil for topical application, capable of efficient release of the incorporated active principle. Liposomes composed of phosphatidylcholine and cholesterol and incorporating Anethi aetheroleum were prepared by thin film hydration method and dispersed into two types of hydrogels (0.5%, respectively 1% carbopol). For the in vitro release kinetics assessment of the entrapped volatile oil we used an adapted Frank diffusion cell. The experimental data were processed to verify different kinetic models, and the obtained results were used to assess the kinetic parameters of the designed hydrogels. Studies have shown that the designed hydrogels follow a 0 order kinetic model after a period of three hours from the beginning of a kinetic experiment. This reinforces the conclusion that liposomes can act as reservoir systems for the controlled release of the entrapped volatile oil.