Romanian Society of Pharmaceutical Sciences
 

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THE INFLUENCE OF STRUCTURAL CHARACTERISTICS ON THE IN VITRO DRUG RELEASE RATE OF TERBINAFINE FROM TOPICAL GELS

MĂNESCU OANA1, MIRON DALIA SIMONA2*, LUPULEASA DUMITRU1, MITU MIRELA ADRIANA1, GOLOCORBIN-KON SVETLANA3, RĂDULESCU FLAVIAN ȘTEFAN4

University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6 Traian Vuia street, 020956, Bucharest, Romania
1Department of Pharmaceutical Technology and Biopharmaceutics,
2Department of Pharmaceutical Physics and Informatics,
3University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Republic of Serbia
4Department of Drug Industry and Pharmaceutical Biotechnologies

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The paper presents the results of correlated, rheological and in vitro drug release evaluation for various hydrophilic gels of terbinafine hydrochloride 1%. Linear dependence was observed between diffusion coefficient values (Higuchi model) and the concentration of cellulose derivative (1 to 4%). For the semisolid systems with concentrations of active pharmaceutical ingredient near the saturation point, selection of the nature and concentration of gel-forming excipients allows an accurate control of the delivery profile.