Romanian Society of Pharmaceutical Sciences
 

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THE INFLUENCE OF STRUCTURAL CHARACTERISTICS ON THE IN VITRO DRUG RELEASE RATE OF TERBINAFINE FROM TOPICAL GELS

MĂNESCU OANA1, MIRON DALIA SIMONA2*, LUPULEASA DUMITRU1, MITU MIRELA ADRIANA1, GOLOCORBIN-KON SVETLANA3, RĂDULESCU FLAVIAN ȘTEFAN4

University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6 Traian Vuia street, 020956, Bucharest, Romania
1 Department of Pharmaceutical Technology and Biopharmaceutics,
2 Department of Pharmaceutical Physics and Informatics,
3 University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Republic of Serbia
4 Department of Drug Industry and Pharmaceutical Biotechnologies

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The paper presents the results of correlated, rheological and in vitro drug release evaluation for various hydrophilic gels of terbinafine hydrochloride 1%. Linear dependence was observed between diffusion coefficient values (Higuchi model) and the concentration of cellulose derivative (1 to 4%). For the semisolid systems with concentrations of active pharmaceutical ingredient near the saturation point, selection of the nature and concentration of gel-forming excipients allows an accurate control of the delivery profile.