THE INFLUENCE OF SOME PSYCHOTROPIC SUBSTANCES ON CONDITIONING USING AN ACTIVE AVOIDANCE PARADIGM
ANCA BUZESCU1, SIMONA NEGREŞ1*, MARA LEFTER1, BRUNO ŞTEFAN VELESCU1, EMIL ŞTEFĂNESCU1, CORNEL CHIRIŢĂ1, FLORICA NICOLESCU2
University of Medicine and Pharmacy ”Carol Davila”, Faculty of Pharmacy, Traian Vuia str. no. 6, Bucharest, Romania
1.Department of Pharmacology and Clinical Pharmacy
2.Department of Toxicology
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The reflexes represent the quick, involuntary responses of the organism to a
stimulus. The mechanisms of both innate and acquired reflex involve the glutamatergic and
the dopaminergic transmissions. The aim of this research was to investigate the effect of
haloperidol and monosodium glutamate on the formation of conditioned reflex in an active
avoidance test, using Wistar rats. Monosodium glutamate(E621, MSG), the sodium salt of
glutamic acid, is regulated in the EU as a flavour enhancing agent (E 621). Haloperidol is
an antipsychotic, blocker of D2 receptors. The results obtained indicate that the two
substances have a negative influence on the formation of conditioned reflexes.
