Romanian Society of Pharmaceutical Sciences
 

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THE INFLUENCE OF PROPOFOL ON HEPATIC ISCHEMIA/REPERFUSION INJURY IN RATS

YANLI ZHANG 1, ZHIHUI CHEN 2, SHUANG SONG 3, WEIWEI ZHONG 1, CHUNMEI FENG 4, HONGLIAN XIA 1*

1.Department of Anaesthesiology, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang City, 157011, China
2.Department of Emergency, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang City, 157011, China
3.Department of Ulteasonic, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang City, 157011, China
4.Department of Pathology, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang City, 157011, China

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This study aimed to evaluate the protective effect of propofol against ultrastructure damage of the rat hepatic tissues in a murine model of hepatic ischemia/reperfusion injury (HIRI), and the underlying mechanism. The treatment with 20 mg/kg bw/h propofol continuously pumped via the femoral vein upon the moment of reperfusion, in the rats that underwent a HIRI model decreased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, downregulated the expression of c-fos, c-jun and P53, upregulated the expression of Bcl-2 and decreased the apoptosis index of hepatocytes and the pathological injuries significantly compared to the model group. Propofol treatment could relieve HIRI in rats, and its mechanism is associated with the regulation of Bcl-2 expressions and downregulation of c-fos and c-jun, which mitigated the damage to the ultrastructure of hepatic tissues.