Romanian Society of Pharmaceutical Sciences

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THE INFLUENCE OF CONTROLLER THERAPY ON CORRELATION BETWEEN FeNO AND ASTHMA CONTROL IN CHILDREN

EUGENIA BUZOIANU1,2*, MARIANA MOICEANU2, FELICIA CORA1,2, DOINA ANCA PLESCA1,2

1University of Medicine and Pharmacy „Carol Davila”, 37 Dionisie Lupu Street, Bucharest
2Department of Pediatrics and Pediatric Neurology, „Victor Gomoiu” Children Clinical Hospital, 21 Basarabia Avenue, Bucharest

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Asthma is a chronic inflammatory disorder of the respiratory tract. Asthma control is directly related to bronchial inflammation control and therefore a major component in the treatment of asthma is the anti-inflammatory controller therapy. FeNO (fractionated exhaled nitric oxide) is a non-invasive marker of atopy and bronchial inflammation and therefore might be useful as objective marker of asthma control. The aim of this study was to assess the way the controller therapy influences the correlation between FeNO value and asthma control in children. For this purpose a prospective study was initiated which included asthmatic children with FeNO measurements and asthma control status assessment, recording also if the patient was receiving or not controller therapy at the moment of the evaluation. Further, the correlation between FeNO value and asthma control status was evaluated, individually for patients who received or not controller therapy. For each of these categories the correlation was also evaluated according to atopy. The results indicate that in children FeNO is correlated with asthma control only in atopic patients receiving controller therapy.