THE INFLUENCE OF CAFFEINE, CELECOXIB AND THEIR COMBINATION ON ANALGESIC PROCESSES
CLAUDIA HANDRA #, ISABEL GHITA *, CINTEZA DELIA #, OANA COMAN, LAURENTIU COMAN #, MARINELA CHIRILA
“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
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Pain and inflammation are the most complex processes that occur in the human body. Pain physiology involves intricate pathways based on a level of reception, transmission pathways and a cortical level. There are numerous neurotransmitters and mediators that influence pain and inflammation as they modulate each level of pain transmission. The purpose of this paper is to determine the analgesic effect of two different substances, celecoxib and caffeine, and the way they influence each other’s effects after both, single and multiple administrations to Swiss albino strain male mice. Two tests were used to determine the analgesic effect, the writhing test and the hot plate test. Following single dose administration, both caffeine and celecoxib determined an increase in the analgesic effect compared to the control group during writhing and hot plate tests. However, no dose-effect relationship could be observed for caffeine. Moreover, caffeine slightly decreased the effects of celecoxib, however without statistical significance. Following multiple dose administration, only the higher doses (10 mg/kg and 25 mg/
g) of caffeine tested had analgesic effects while celecoxib showed analgesic effects only in the hot plate test. Caffeine had no influence on analgesic effects of celecoxib following multiple dose administration. The results of IL-6 and CPR determinations suggest that the analgesic effects of celecoxib could be mediated by pro-inflammatory cytokines. Caffeine did not affect IL-6 and CRP levels.