Romanian Society of Pharmaceutical Sciences
 

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THE INFLUENCE OF BIDENS TRIPARTITA EXTRACTS ON PSYCHO-MOTOR ABILITIES AND COGNITIVE FUNCTIONS IN RATS

CĂTĂLINA ELENA LUPUȘORU1, ELIZA GRAȚIELA POPA2, RAUL BOGDAN SANDU1, BEATRICE ROZALINA BUCA1, LILIANA MITITELU-TARȚĂU1*, RAOUL VASILE LUPUȘORU3

“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iași, Romania
1.Faculty of Medicine, Department of Pharmacology-Algesiology
2.Faculty of Pharmacy, Department of Pharmaceutical Technology
3.Faculty of Medicine, Department of Patho-Physiology

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The aim of the present study was the investigation of the effects of two Bidens tripartita (B. tripartita) extracts on the spatial working memory in rat. The experiments were carried out on white Wistar rats (4 groups of 6 animals each), treated intraperitoneally, as follows: Group I (Control): saline solution 0.1 mL/10 g b.w.; Group II (BT-alcoholic): 200 mg/kg b.w. B. tripartita alcoholic extract; Group III (BT-aqueous): 250 mg/kg b.w. B. tripartita aqueous extract; Group IV (Mg): 1 mmol/kg b.w. magnesium chloride. The effects on the psycho-motor abilities and cognitive functions were evaluated using the T-maze test, in order to investigate the influence of these two vegetal extracts on the short-term memory of laboratory animals. B. tripartita aqueous extract determined a significant increase of the spontaneous alternation percentage, but less accentuated than magnesium in the T-maze test in rats. The administration of B. tripartita alcoholic extract was associated with a significant augmentation of the spontaneous alternation rate, but less intense than those produced by the aqueous extract in this behavioural model. The treatment with both B. tripartita aqueous and alcoholic extracts resulted in a facilitation of spatial learning, an improvement of the short-term memory and a weak anxiolytic effect in rat.