Romanian Society of Pharmaceutical Sciences
 

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THE INFLUENCE OF A NEW RUTIN DERIVATIVE ON HOMOCYSTEINE, CHOLESTEROL AND TOTAL ANTIOXIDATIVE STATUS IN EXPERIMENTAL DIABETES IN RAT

ELENA ALBU1, DAN LUPAŞCU2*, CRISTIANA FILIP3, IRINA M. JABA1, NINA ZAMOSTEANU3

1Department of Pharmacology, „Grigore T. Popa” University of Medicine and Pharmacy, Str.Universitatii nr.16, 700115 Iasi, Romania.
2 Department of Pharmaceutical Chemistry, „Grigore T. Popa” University of Medicine and Pharmacy, Str.Universitatii nr.16, 700115 Iasi, Romania.
3 Department of Biochemistry, „Grigore T. Popa” University of Medicine and Pharmacy, Str.Universitatii nr.16, 700115 Iasi, Romania.

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Diabetes is a widely spread metabolic disease that involves disturbances in the glucose, lipid and mineral levels, as well as in redox reactions. One of the major risk factors in diabetes is the cardiovascular disease and its complications. Several biochemical parameters such as hypercholesterolemia, hyperhomocysteinemia and the reactive species are considered aggravating factors for the diabetes. The first therapeutic option in diabetes is to lower glucose levels and most often to decrease these major risk factors. The study investigated the influence of a new rutin derivative (coded L3) on the previously mentioned risk factors in experimentally-induced diabetes in rats. L3 contains a pyrimidine group attached to the rutin molecule. We envisaged two pharmacological activities for this compound: the effect of lipid level decrease and an anti-oxidative activity. Diabetes was induced by a single dose of 110 mg/kg bw of alloxan. The influence of L3 over the diabetic status was determined measuring the levels of glucose, cholesterol, homocysteine and total antioxidant status (TAS) initially and after one month of previous alloxan and L3 administration. The obtained data suggest that the new rutin derivative, coded L3, presents anti-oxidative properties and decreases cholesterol and homocysteine levels, thus conferring protection against certain major risk factors in diabetes.