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THE INFLUENCE OF A NEW RUTIN DERIVATIVE IN AN EXPERIMENTAL MODEL OF INDUCED HYPERHOMOCYSTEINEMIA IN RATS

CRISTIANA FILIP ¹, ELENA ALBU ^2*, DAN LUPAȘCU ³, NINA FILIP ¹

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Cardiovascular diseases are a major cause of deaths today. It is generally accepted the involvement of three major risk factors: hyperlipidaemia, hyperhomocysteinemia and the molecular reactive species excess. Therapeutic approaches try to reduce the levels of lipids and homocysteine and to keep the balance between the oxidation/reduction system. We studied a new rutin derivative coded L103 that may determine the lowering of the lipid level and antioxidant properties. L103 contains a pyridine group attached to a rutin molecule. We studied the influence of L103 on the plasmatic levels of cholesterol, total antioxidant status and homocysteine in hyperhomocysteinemia experimentally induced in a rat model through methionine loading. The obtained data suggest that L103 succeeds to prevent the decline of the total antioxidant status, keeps cholesterol within normal ranges but has minor effects on the homocysteine levels. Despite the low influence on homocysteine, L103 confers protection against two of the major risk factors incriminated in cardiovascular diseases.