Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 4/2013

THE IN VITRO RELEASE MECHANISM OF IBUPROFEN FROM CONVENTIONAL AND SPECIAL DOSAGE FORMS

DOINA DRĂGĂNESCU1, ELENA POPA DANIELA2, DUMITRU LUPULEASA3, GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU2, SIMONA MIRON DALIA1, ADRIAN COSMIN ROŞCA4*, RAZVAN-DANIEL CHIVU5

University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6th Traian Vuia street, 020956, Bucharest, Romania.
1Department of Pharmaceutical Physics and Informatics,
2Department of Drug Control,
3Department of Pharmaceutical Technology and Biopharmaceutics,
4Ovidius University Constanta, Faculty of Pharmacy, Department of Drug Control, Constanta, Romania
5University of Medicine and Pharmacy „Carol Davila” Faculty of Medical Midwifery and Nursing Bucharest, Romania

Download Full Article PDF

Six pharmaceutical dosage forms (sugar coated tablets, hard and soft gelatin capsules, oral suspension and rectal suppositories), containing various concentrations of ibuprofen as single active ingredient, were evaluated in vitro, based on the available compendial recommendations. Several methodological adaptions were implemented, in order to adequately address the particularities of the formulations and the rate-limiting step of the release process. The analysis of the mean dissolution profiles was focused on applicability of different kinetic models, possible explanations for observed similarities or non-similarities and on the foreseen limitations in applicability of the test conditions, in the context of biowaiver.