Romanian Society of Pharmaceutical Sciences
 

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THE IN VITRO INFLUENCE OF A PHARMACEUTICALLY ACTIVE SMALL SEA FISH EXTRACT ON APOPTOSIS AND PROLIFERATION MECHANISMS AMPLIFIED BY INFLAMMATORY CONDITIONS

LAURA OLARIU 1,2, BRINDUSA DUMITRIU 1, LUIZA CRACIUN 1, EMILIA BUSE 1, NATALIA ROSOIU 2,3, MIHAI BOJINCA 4*, TOMA PAPACOCEA 5

1.S.C. Biotehnos S.A., 3-5 Gorunului Street, 075100-Otopeni, Ilfov, Romania
2.Academy of Romanian Scientists, 54 Splaiul Independentei 050094, Bucharest, Romania
3.Ovidius University, Faculty of Medicine, Department of Biochemistry, Constanța, Romania
4.Spitalul Dr.I. Cantacuzino, Clinica de Medicina Interna si Reumatologie
5.University of Medicine and Pharmacy “Carol Davila” Bucharest, Neurosurgery Dept. “St. Pantelimon” Emergency Hospital

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The osteoarthritis pathogenesis is depicted by the start of articular cartilage degradation and dysfunction in chondrocytes metabolism. Many drugs were developed in order to prevent or stop one or several pathways of osteoarthritis progression, but a therapeutically efficient solution is far from been achieved. Our research is focused on apoptotic and cell division mechanisms, dramatically changed in osteoarthritis, highlighting inflammatory conditions mimicked through two types of stimuli: IL1β and TNFα. The protective action of a small sea fish extract was studied on a human chondrocytes cell line (CHON-001), comparing its action with two pharmaceutically active compounds: chondroitin sulphate and ascorbic acid. The previously demonstrated regenerating effect of the product is completed with anti-apoptotic and pro-mitotic action in pro-inflammatory stimulated chondrocytes, as well as the hyaluronic acid extracellular restoring in IL1β treated CHON-001.