Romanian Society of Pharmaceutical Sciences
 

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THE IMPORTANCE OF CHEMOTHERAPY IN THE MANAGEMENT STRATEGIES REGARDING HEPATIC METASTASES IN COLORECTAL CANCER

OCTAV GINGHINĂ1, GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU2, CAROLINA NEGREI3*, MARIA BÂRCĂ2

1.”Sf. Ioan” Hospital, Department of Oncological Surgery, “Carol Davila” University of Medicine and Pharmacy, Faculty of Dental Medicine, 13, Vitan-Barzesti Street, 042122, Bucharest, Romania
2.Department of Drug Control, “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6, Traian Vuia Street, 020956, Bucharest, Romania
3.Department of Toxicology, “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6, Traian Vuia Street, 020956, Bucharest, Romania

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The liver is the most common site for haematogenous metastases in colorectal cancer. Over the past ten years the survival rate in patients with hepatic metastases has significantly improved, mostly because of the development of new chemotherapy protocols, as well as new therapeutic agents. Overall, these are strengthening the effects of surgery, which in case of radical resection offers the best survival. Moreover, surgical control of liver metastatic extensive disease can combine resection with ablation therapies or staged methods. Today, the treatment of colorectal cancer liver metastases is essentially multidisciplinary, the medical oncologist together with the surgeon and the gastro-enterologist deciding the therapeutical sequence individualised for each patient.