Romanian Society of Pharmaceutical Sciences
 

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THE IMPACT OF URAPIDIL USE IN HYPERTENSION PREHOSPITAL EMERGENCY INTERVENTION

GABRIELA PRODAN (PURA) 1,3, DANIEL-CORNELIU LEUCUȚA 2*, GABRIEL MARC 1, HORIA SIMU 3, CRISTINA NASTASĂ 1, OVIDIU ONIGA 1

1.Department of Pharmaceutical Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012, Cluj-Napoca, Romania
2.Department of Medical Informatics and Biostatistics, “Iuliu Hațieganu” University of Medicine and Pharmacy, 6 Louis Pasteur Street, RO-400012, Cluj-Napoca, Romania
3.Department of Ambulance Emergency Service, 55 Horea Street, RO-400202, Cluj-Napoca, Romania

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The aim of this study was to determine if urapidil, used as a first-line emergency antihypertensive agent represents, in prehospital interventions, a superior choice if it is administered after other antihypertensive drugs. The paper presents the results of a retrospective study, based on the medical records of 100 interventions of the Cluj County Ambulance Service, Romania, for patients with hypertensive crisis. There have been identified significant differences on both intervention time and time duration until blood pressure normalizes, for the patients that received urapidil was administered as a first-line antihypertensive, compared to the patients for that received urapidil after other antihypertensive drugs. These preliminary results can support the use of urapidil as a first-choice antihypertensive agent in prehospital emergency treatment, in hypertensive outbreak.