Romanian Society of Pharmaceutical Sciences
 

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THE IMPACT OF DISSOLUTION MEDIA ON THE SIMILARITY OF RELEASE PROFILES OF TRIMETAZIDINE DIHYDROCHLORIDE FROM IMMEDIATE RELEASE TABLETS

MOURAD ALI1, MIRON DALIA SIMONA2*, LUPULEASA DUMITRU1, KARAMPELAS OANA1, RĂDULESCU FLAVIAN ȘTEFAN3, DRAGANESCU DOINA4, ROȘCA ADRIAN COSMIN5

University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6 Traian Vuia street, 020956, Bucharest, Romania
1Department of Pharmaceutical Technology and Biopharmaceutics,
2Department of Pharmaceutical Physics and Informatics,
3Department of Drug Industry and Pharmaceutical Biotechnologies.
4Department of Pharmaceutical Physics and Informatics
5Department of Drug Analysis, Faculty of Pharmacy, "Ovidius" University of Constantza, Romania

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The paper presents the impact of the composition of the dissolution media (water, hydrochloric acid pH=1.2 and phosphate buffer pH=6.8) on the in vitro release profiles of four immediate release formulations containing 20 mg trimetazidine dihydrochloride. The results suggest that, for quality control purposes, the most discriminatory test conditions are provided by the acidic media.