Romanian Society of Pharmaceutical Sciences

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THE EFFICIENCY OF LOW MOLECULAR WIGHT HEPARINS IN THE PROPHYLAXIS OF VENOUS THROMBOEMBOLIC COMPLICATIONS IN GENERAL SURGERY

ANDREEA NICOLETA SAFTA1, VLAD DENIS CONSTANTIN2, LAURA-ILEANA SOCEA3, BOGDAN SOCEA2*

1Bucharest Health Insurance Department
2Surgery Clinic. “St. Pantelimon” Clinical Emergency Hospital, Bucharest
3Organic Chemistry Department, Faculty of Pharmacy, Bucharest

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Deep venous thrombosis (DVT), with its possible serious consequences (pulmonary thromboembolism- PTE- which can lead to death) often influence the morbidity and mortality of surgical interventions, especially in the field of general surgery, traumatology, orthopedy, gynecology and urology. In a retrospective study on 3875 patients hospitalized and operated in the Surgery Clinic of “St. Pantelimon” Emergency Hospital, Bucharest, Romania, during 2002- 2006, patients that benefited of thromboprophylaxis with low molecular weight heparins (LMWH), there were analysed the risk factors for DVT and PTE, the efficiency of the therapy and hemorrhagic complications. LMWH represent safe thromboprophylactic agents, the postop hemorrhagic complications of the treated patients being minor, benefits exceeding risks. The rate of hemorrhagic complications was 2.04%, most of them being approached in the conservative manner (97.5% of them). Only 2 cases of haemoperitoneum needed surgical interventions, which represents 0.5% in a thousand of patients treted with LMWH. On the other hand, the rate of thombotic complications lowered under 1% (0.92%) and death by PTE occured in 3 cases (0.077%). From the patients submitted to prophylaxis with LMWH, who nevertheless developed thomboses (inefficient thromboprophylaxis), 44.44% were patients with neoplastic diseases, an association which is statistically significant. Thus, neoplastic disease represents both a risk factor and an important factor for the inefficiency of the thromboprophylaxis with LMWH.