Romanian Society of Pharmaceutical Sciences
 

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THE EFFECTS OF SOY ISOFLAVONES AND HORMONAL REPLACING THERAPY ON THE INCIDENCE AND EVOLUTION OF POSTMENOPAUSAL FEMALE URINARY INCONTINENCE

ADRIAN BUMBU1, PAŞCA BIANCA2, DELIA MIRELA TIT2*, SIMONA BUNGAU2, GHEORGHE BUMBU1

1.University of Oradea, Faculty of Medicine and Pharmacy, Surgical Disciplines Department, 10 Decembrie 1 St., Oradea, Romania
2.University of Oradea, Faculty of Medicine and Pharmacy, Pharmacy Department, 29 N. Jiga St., Oradea, Romania

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The objective of our study was to determine the comparative effects of soy isoflavones and low doses of systemic hormonal therapy (SHT) on the evolution and incidence of urinary incontinence in postmenopausal women, who were continent at treatment initiation. This study lasted 12 months and included 215 postmenopausal women who were divided into three groups: the first comprised 78 women treated with soy extract (40% isoflavones); the second group 65 women with continuous combined hormonal preparation based on 1 mg oestradiol and 0.5 mg noretisterone acetate (NETA) p.o. daily; whereas the control group 72 women with no therapy. The Revised Urinary Incontinence Scale (RUIS) scores and the incidence of different types of urinary incontinence were determined at 0, 6, and 12 months. Our results showed that neither the first treatment nor the second significantly influenced the time-dependent evolution of these parameters. Therefore, the present study provides pertinent evidence that the two therapies investigated have no effect in preventing female post-menopausal urinary incontinence.