Romanian Society of Pharmaceutical Sciences
 

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THE EFFECTS OF NEW 1,3-THIAZOLIDINE-4-ONES WITH PYRRAZOLONE SCAFOLD ON MOTOR FUNCTION IN MICE

MARIA APOTROSOAEI 1, IOANA MIRELA VASINCU 1*, SANDRA MĂDĂLINA CONSTANTIN 1, ANDREEA-TEODORA IACOB 1, GEORGIANA-ROXANA TAUȘER 1, DAN LUPAȘCU 1, CĂTĂLINA-ELENA LUPUȘORU 2, LENUȚA PROFIRE 1

1.”Grigore. T. Popa” University of Medicine and Pharmacy Iași, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Universității Street, no. 16, 700115, Iași, Romania
2.”Grigore. T. Popa” University of Medicine and Pharmacy Iași, Faculty of Medicine, Department of Pharmacology, Clinical Pharmacology and Algesiology, Universității Street, no. 16, 700115, Iași, Romania

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The aim of this study was to investigate the effects of new 1,3-thizolidine-4-ones with pyrazolone scaffold (7a-m) on motor function in mice, using RotaRod performance and spontaneous locomotor activity tests. The toxicity screening of these compounds was also performed. The results of RotaRod performance test showed that the compounds don’t have appreciable negative influence on neuromuscular activity, the recorded values being comparable with those of phenazone and control, so it could be appreciated that these compounds don’t have neurotoxic effects. In the case of spontaneous locomotor activity test, the most intense negative effect was observed for 7j (3-OH,4-OCH3), for which the horizontal and vertical movements were lower than phenazone and control at all three-time intervals (1h, 2h, 4h). For other derivatives no appreciable negative effect on spontaneous locomotor activity was observed. Referring to the toxicity degree, all tested compounds showed lower toxicity in reference with phenazone, which supports the favourable influence of 1,3-thiazolidine-4-one moiety on pyrazolone scaffold.