« Back to Farmacia Journal 5/2022

THE EFFECT OF METHYLPREDNISOLONE COMBINED WITH MACROLIDE ANTIBIOTICS ON MYCOPLASMA PNEUMONIAE PNEUMONIA IN CHILDREN

JING WANG, YING ZHANG *

Download Full Article PDF

This study aimed to evaluate the clinical efficacy of the combination of methylprednisolone (MP) and macrolide antibiotics (MA) in the treatment of Mycoplasma pneumoniae pneumonia (MPP) in children. Sixty children with MPP were selected as research subjects and were randomly divided into an experimental group and a control group, with 30 patients in each group. The children in the experimental group were treated with MP + MA, and those in the control group were treated only with MA. The treatment efficacy, improvement of clinical symptoms, improvement in the quality of life, and adverse reactions of the two groups of children were compared before and after the treatment. The combination of MP and MA shower increased efficacy compared with the treatment with MA alone (p < 0.05) translated by a shorter time of clinical symptoms alleviation, improved in the quality of life, improve in the levels of tumour necrosis factor α (TNF-α), high-sensitivity C-reactive protein (Hs-CRP), and CD4+ levels. Moreover, in the experimental group it was observed a lower rate of adverse reactions after treatment compared with those in the in the control group (p < 0.05). In conclusion, for the treatment of MPP in children, the combined treatment with MP and MA showed a superior effect, which could improve the clinical treatment effect, relieve the clinical symptoms, effectively shorten the hospital stay, improve the prognosis, promote the improvement in quality of life of children, and enhance the immune function of children. Therefore, it is worthy of clinical application and promotion.