THE EFFECT OF LIPOSOMAL EPIGALLOCATECHIN GALLATE AND METOCLOPRAMIDE HYDROCHLORIDE CO-ADMINISTRATION ON EXPERIMENTAL MIGRAINE
ADRIANA ELENA BULBOACĂ 1, ALINA PORFIRE 2, CRISTINA BARBĂLATĂ 2, SORANA D. BOLBOACĂ 3*, CRISTINA NICULA 4, PAUL MIHAI BOARESCU 1, IOANA STĂNESCU 5, GABRIELA DOGARU 6
“Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
1.Department of Pathophysiology
2.Department of Pharmaceutical Technology and Biopharmaceutics
3.Department of Informatics and Biostatistics
4.Department of Ophthalmology
5.Department of Neurosciences
6.Department of Medical Rehabilitation
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Epigallocatechin gallate (EGCG) has been intensively studied for its anti-oxidative, anti-inflammatory and anti-nociceptive
effects. Our study aimed to assess the beneficial effect of liposomal EGCG (L-EGCG) co-administered with metoclopramide
(MC) on oxidative stress and pain in experimental migraine induced by i.p. nitroglycerine (NG) administration in rats. Five
groups of randomly divided rats (7/group) were investigated: control (C, group 1) with i.p. administration of saline solution,
NG control group (group 2), NG+MC (group 3), NG+MC+EGCG group (group 4), and NG+MC+L-EGCG (group 5). The
nociception was appreciated by the formalin test and the oxidative stress/anti-oxidant status by serum tests. MC alone
significantly improved the nociception process and the oxidative stress parameters but not the antioxidative status. Adding
EGCG to MC significantly reduced the oxidative stress and antioxidant status together with decreasing of nociception, with
better results for L-EGCG.