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THE EFFECT OF EXTRACTION METHOD OF VERNONIA AMYGDALINA DELILE. LEAVES ON CARDIOTONIC EFFECT

DENNY SATRIA 1*, URIP HARAHAP 2, AMINAH DALIMUNTHE 2, TRIANA HERTIANI 3, RONY ABDI SYAHPUTRA 2, MAHATIR MUHAMMAD 1, NASRI NASRI 1,4

1Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No. 5 Kampus USU, Medan, Sumatera Utara, Indonesia
2 Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No. 5, Kampus USU, Medan, Sumatera Utara, Indonesia
3 Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Yogyakarta,
4 Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan (STIKes) Senior Medan, Jl. Jamin Ginting KM.8,5 No.13, Mangga, Medan Tuntungan, Sumatera Utara, Indonesia

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Vernonia amygdalina Delile leaves contain secondary metabolites that prevent heart disease. This study aims at demonstrating the cardiotonic effect of various ethanolic extracts obtained with simplicia powder of African leaf. In this direction, we tested the effect of African leaf ethanolic extract on normal rat heart isolates and determined its effect on heart contractility and heart rate. The results showed that the highest cardiac glycoside content in the ethanolic extract obtained by reflux extraction was 30.05 ± 0.13 mg/g. In an inotropic test, the same extract with a concentration of 1 mg/mL increased contractility by 74.02%, and regarding the chronotropic test, an 22.68% increase was observed. African leaf ethanolic extract (from Vernonia amygdalina Delile), obtained using reflux method, with a 1 mg/mL concentration, exhibited positive inotropic and chronotropic activity.