THE DYNAMICS OF ADIPONECTIN AND LEPTIN ON METABOLIC SYNDROME PATIENTS AND AGE MATCHED HEALTHY SUBJECTS
MOHAMAD ABDULWAHABE MOHAMAD1, NICULINA MITREA1, ALINA-CRENGUȚA NICOLAE1*, MARIA-ZINAIDA CONSTANTINESCU1, CRISTINA MANUELA DRĂGOI1, ANDREEA-LETIȚIA ARSENE1, CARMEN GABRIELA BARBU2,3
1.Biochemistry Departament, „Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Traian Vuia St. 6, Bucharest, Romania
2.Endocrinology Department, „Carol Davila” University of Medicine and Pharmacy
3.Elias Emergency University Hospital, Mărăști St. 17, Bucharest
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The metabolic syndrome is a complex combination of interrelated risk factors of
metabolic origin that, when occurring together, increase the risk of developing
cardiovascular disease and diabetes.
Adipocytokines are bioactive mediators released from the adipose tissue
including adipocytes and other cells present at the level of fat tissues. These include several
novel and highly active molecules released abundantly by adipocytes like leptin, resistin,
adiponectin, as well as some more classical cytokines released possibly by inflammatory
cells infiltrating fat, like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).
The most abundantly expressed cytokines within the adipose tissue are leptin and
adiponectin [1, 3].
Adiponectin, is highly expressed in adipose cells, and circulates in high
concentrations in the blood. Decreased serum levels of adiponectin are associated with
insulin resistance. The role of adiponectin in systemic inflammation and critical illness is
not well defined. The variability in the serum adiponectin levels is partly attributed to
various options for modulation of this hormone.
Leptin, correlates directly with the mass of adipose tissue and its main function
is to control the appetite and exerts its various actions on glucose metabolism and energy
expenditure via binding to the leptin-receptor in the brain and peripheral tissues as liver,
pancreas, adipose tissue and in the immune system .
In this study, we assessed the levels of adiponectin and leptin in lean and obese
subjects with associated dislipidemy and diabetes.