Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 6/2018

THE CAT AND SOD ACTIVITIES IN PATIENTS WITH CHRONIC SUPPURATIVE OTITIS MEDIA

ROXANA ȘERBAN 1#, CODRUȚA BĂDESCU 2#, ALEXANDRU FILIP 3#*, MIHAIL DAN COBZEANU 4#, MAGDA BĂDESCU 1#, CORINA BUTNARU 4#, BOGDAN HUZUM 5#, CRISTIANA FILIP 6#

1.University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Pathophysiology Department, 16 Universității Street, 700115, Iasi, Romania
2 .University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Internal Medicine, 16 Universității Street, 700115, Iasi, Romania
3 .University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Orthopaedic and Traumatology, 16 Universității Street, 700115, Iasi, Romania
4 .University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Otorhinolaryngology Department, 16 Universității Street, 700115, Iasi, Romania
5 .University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, 16 Universității Street, 700115, Iasi, Romania
6 .University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Biochemistry, 16 Universității Street, 700115, Iasi, Romania

Download Full Article PDF

Oxidative stress plays an important role in multiple diseases by disturbing the oxidant-antioxidant balance. The aim of this study was to evaluate the antioxidative status in patients with chronic suppurative otitis media (CSOM). We conducted a prospective study that included 60 patients diagnosed with chronic suppurative otitis media with and without cholesteatoma. The catalase (CAT) and superoxide dismutase (SOD) activities were determined in erythrocytes respectively serum of the patients. We noticed that the antioxidant enzyme SOD activity in the patients with CSOM with and without cholesteatoma had statistically significant lower values compared to the healthy subjects (p < 0.05). For the same groups the CAT activity was statistically significant increased (p < 0.05) as compared to the healthy group. As a conclusion, oxidative stress seems to be involved in the pathogenesis of CSOM with and without cholesteatoma, leading to chronic infections and tissue injury.