Romanian Society of Pharmaceutical Sciences

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SYNTHESIS OF SOME 1,4-DISUBSTITUTED THIOSEMICARBAZIDES AS INTERMEDIATES FOR THE SYNTHESIS OF 1,3,4-THIADIAZOLE DERIVATIVES

TUNDE HORVATH1*, GEORGETA ŞERBAN1, STELA CUC2

1University of Oradea, Faculty of Medicine and Pharmacy, Pharmaceutical Chemistry Department, 29 Nicolae Jiga, 410028 Oradea, Romania
2University of Waterloo, Department of Earth Sciences, Environmental Isotope Laboratory, Waterloo, Ontario, Canada

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The 4-phenyl-1-[α-acylamino-β-(p-X-phenyl)]acriloyl thiosemicarbazides 3a-h were synthesized using 2-R-4-(p-X-benzylidene)-oxazol-5-ones 1a-h as starting materials. The reaction of compounds 1a-h with hydrazine hydrate led to the formation of acid hydrazides 2a-h. The thiosemicarbazide derivatives 3a-h were obtained by nucleophilic addition of corresponding acid hydrazides 2a-h to phenylisothiocyanate. The newly synthesized compounds structures were elucidated by spectral data and elemental analysis.