Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS OF NEW N-SUBSTITUTED HETEROCYCLIC SULFONAMIDES

ADRIANA HANGAN1*, ANDREEA BODOKI1, LUMINITA OPREAN1, OVIDIU CRISAN2, ILISCA MIHALCA3

1Departament of Inorganic Chemistry, University of Medicine and Pharmacy “Iuliu Hatieganu”, 12 Ion Creanga, RO-400010, Cluj-Napoca
2Departament of Organic Chemistry, University of Medicine and Pharmacy “Iuliu Hatieganu”, 8 Victor Babes, RO-400012, Cluj-Napoca
3Department of Organic Chemistry and CCSOOM, Babes-Bolyai University, 11Arany Janos, RO-400028, Cluj-Napoca, Romania

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A new series of N-substituted sulfonamides derivatives of thiadiazole ring were synthesized using the Vogel method (L1-L6). The obtained compounds may coordinate a variety of metallic ions (Cu2+, Fe2+, Zn2+, Mn2+, etc.) and the resulting complexes may exhibit a wide range of biological activities (antimicrobial, anti-inflammatory, nuclease and superoxide dismutase-like activity). The structures of the newly synthesized compounds were confirmed by elemental analysis and spectroscopic (MS, IR, 1H-NMR) data.