Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF CU(II), NI(II), CO(II) AND MN(II) BINUCLEAR COMPLEXES DERIVED FROM 1,3-BIS(2’-FORMYLPHENYL)-1,3-DIOXAPROPANE AND L-TRYPTOPHAN

FLORINA CIOLAN1*, LUMINIŢA PATRON2, LUMINITA MARUTESCU3, MARIANA CARMEN CHIFIRIUC3

1.University of Craiova, Faculty of Exact Sciences, Department of Chemistry, 107 I Calea Bucureşti, Craiova, 200478, Romania
2.Romanian Academy, “Ilie Murgulescu” Institute of Physical Chemistry, 202 Splaiul Independenţei, Bucharest, 060021, Romania
3.University of Bucharest, Faculty of Biology, Microbiology-Immunology Department, Aleea Portocalelor 1-3, sect. 5, Bucharest, Romania

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A novel series of binuclear complexes of the [M2L(AcO)2(H2O)4] type, where M= Cu(II), Ni(II), Co(II) or Mn(II) and L= (C39H34N4O6)2-, were synthesized by template condensation of 1,3-bis(2′-formylphenyl)-1,3-dioxapropane, L-tryptophan and metal acetate in methanolic medium. The complexes of M(II):L (2:1) type were characterized by elemental analyses, molar conductivity measurements, IR, electronic spectra and magnetic susceptibility measurements. The low value of molar conductivity indicates them to be non-electrolytes. Based on the magnetic and electronic spectral data, an octahedral / distorted octahedral geometry may be proposed for all the complexes. The new complexes were screened for their antimicrobial activity towards ten microbial strains, by qualitative and quantitative assays. Our results indicated that the [Cu2L(AcO)2(H2O)4] complex was the most active of the studied compounds, concerning both the intensity of the antimicrobial activity and the microbial spectrum.