Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 5/2013

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL 2-ARYLIDEN-HYDRAZONETHIAZOLES

CRISTINA NASTASĂ1*, BRÎNDUŞA TIPERCIUC1, SMARANDA ONIGA2, ADRIAN PÎRNĂU3, MIHAELA IONESCU4, DORA TĂRLUNGEANU1, MARIANA PALAGE2, PHILIPPE VERITÉ5, OVIDIU ONIGA1

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 41 Victor Babeş Street, RO-400010 Cluj-Napoca, Romania
2Department of Therapeutical Chemistry, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 41 Victor Babeş Street, RO-400010 Cluj-Napoca, Romania
3National Institute for Research and Development of Isotopic and Molecular Technologies, RO-400293 Cluj-Napoca, Romania
4Department of Microbiology, Faculty of Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Pasteur Street, RO-400015 Cluj-Napoca, Romania
5Department of Analytical Chemistry, University of Medicine and Pharmacy Rouen, 22 Boulevard Gambetta, F-76183 Rouen Cedex, France

Download Full Article PDF

A new series of 2-aryliden-hydrazone-thiazoles 3a-l was synthesized starting from aryliden-thiosemicarbazones by the Hantzsch condensations with different α (or γ)- halocarbonyl compounds. The newly synthesized compounds were screened for their antimicrobial activity against 4 bacterial strains: Staphylococcus aureus (ATCC 29213), Bacillus subtilis (ATCC 60511), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 10145) and one fungal strain: Candida albicans (ATCC 10231). The compounds 3i and 3j demonstrated a good inhibitory activity against E. coli. The results of the antifungal screening showed that the compounds 3a-d and 3f-j presented an excellent activity against Candida albicans.