Romanian Society of Pharmaceutical Sciences
 

« Back to Farmacia Journal 5/2017

SYNERGISTIC EFFECS OT THE DOXEPIN-CANDESARTAN COMBINATION ON THE THERMOALGESIC SENSIBILITY IN MICE

DANIELA CARMEN ABABEI 1, SORIN BEȘCHEA CHIRIAC 5*, WALTHER BILD 2,3, CARMEN SOLCAN 5, ANDREI LUCA 4, RĂZVAN NICOLAE RUSU 1, DELIA BULEA 1, VERONICA BILD 1,2,4

1.“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmacodynamics and Clinical Pharmacy Department, Iași, Romania
2.Center of Biomedical Research of the Romanian Academy, Iași, Romania
3.”Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, Physiology Department, Iași, Romania
4.”Grigore T. Popa” University of Medicine and Pharmacy, CEMEX Department, Iași, Romania
5.”Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Iași, Romania

Download Full Article PDF

Given the multitude of neuromodulators involved in the generation and transmission of pain, two therapeutic agents with different action mechanisms (an antidepressant - doxepin and an angiotensin-AT1 receptor blocker - candesartan) have been associated in this study. None of the substances is used exclusively as analgesic, but increasingly as adjuvants. The hot-plate test at 52.5°C was used as a study method of the thermal stimulation nociception. For the analysis of the interaction, the additive composite method was used. The study was performed on Swiss mice weighing 18 - 22 grams, which received oral administration of the drugs, either single or combined work-ups. The data obtained demonstrated a synergic type interaction (Zadd = 7.74 ± 0.92, Zmix = 1.82 ± 0.36, p1 = 0.931, p2 = 0.069, = 0.5, γ = 0.282, Tc = 6.20, Tt = 3.79, Fc = 15.30, Ft = 5.14, p < 0.001) between doxepin and candesartan. Both substances exhibited antinociceptive effects per se, and the fixed-ratio combination proved to be synergistic.