Romanian Society of Pharmaceutical Sciences

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SUPERCRITICAL FLUID TECHNOLOGY AND SUPERCRITICAL FLUID CHROMATOGRAPHY FOR APPLICATION IN GINSENG EXTRACTS

MAYYA PETROVNA RAZGONOVA 1, ALEXANDER MIKHAILOVICH ZAKHARENKO 1, TATIANA KUZMINICHNA KALENIK 2, ALEXANDER EVGENYEVICH NOSYREV 3, ANTONIS K. STRATIDAKIS 4, YAROSLAV OLEGOVYCH MEZHUEV 5, TATYANA I. BURYKINA 6, ALINA CRENGUȚA NICOLAE 7, ANDREEA LETIȚIA ARSENE 7, ARISTIDIS MICHAEL TSATSAKIS 3,4,5, KIRILL SERGEYEVICH GOLOKHVAST 1,8*

1.Scientific Education Center in Nanotechnology, Far-Eastern Federal University, Vladivostok, Far East, Russian Federation
2.School of Biomedicine, Far-Eastern Federal University, 690950, Vladivostok, Far East, Russian Federation
3.Central Chemical Laboratory of Toxicology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
4.Laboratory of Toxicology, School of Medicine, University of Crete, Heraklion 71003, Greece
5.Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya Square, 9, Moscow 125047, Russian Federation
6.Department of Analytical and Forensic Medical Toxicology, Sechenov University, Moscow 119991, Russian Federation
7.Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
8.Pacific Geographical Institute FEB RAS, 7 Radio street, Vladivostok, 690041, Russian Federation

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This research review deals with the study of the scientific articles, published during the last two decades that are devoted to the extraction of ginsenosides from different types of ginseng with the use of supercritical CO2(SC - CO2). Different types of ginseng are being the object of investigation including Panax ginseng C.A. Meyer, Brazilian ginseng (Pfaffia paniculata, Pfaffia glomerata, Hebanthe eriantha) and North American ginseng (Panax quinquefolius). It was shown that the extraction and fractionation of Panax ginseng C.A. Meyer using SC-CO2 technology is a very effective way for extracting biologically active plant components, such as ginsenosides, kudinosides, polysaccharides, polyphenolic compounds and stauntosides. In addition, it was exhibited that SC-CO2 technology could increase considerably the yield in antioxidant fractions in which the concentration of bioactive components of a P. ginseng C.A. Meyer are high. At last, this review also considers the application of supercritical CO2 fluid chromatography for Panax ginseng. The review aspired to investigate the contents and to compare other ways of extraction with supercritical extraction and to show its efficiency and also use of new “green technologies”.