Romanian Society of Pharmaceutical Sciences
 

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STUDY OF THE COMPLEXATION BEHAVIOR OF TENOXICAM WITH CYCLODEXTRINS

LENUŢA-MARIA ŞUTA1*, LAVINIA VLAIA1, V. VLAIA2, IOANA OLARIU1, DANIEL I. HĂDĂRUGĂ3, C. MIRCIOIU4

1“Victor Babeş” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
2“Victor Babeş” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
3“Politehnica” University of Timişoara, Faculty of Industrial Chemistry and Environmental Engineering, 2 Victory Square, 300006, Timişoara, Romania
4“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Applied Mathematics and Biostatistics, 6 Traian Vuia St., 020956, Bucharest, Romania

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Tenoxicam (T) is a lipophilic nonsteroidal anti-inflammatory agent, very slightly soluble in water, often used in the treatment of rheumatic and arthritic diseases for its antiinflammatory, analgesic and antipyretic properties. In order to increase its solubility in water, inclusion complexes of tenoxicam with α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) were obtained. In order to obtain the complexes as particles of small (nanometric) dimensions, complexation by the co-precipitation, kneading and ethanol-water solution methods was used. The obtained inclusion complexes were characterized through Scanning Electron Microscopy (SEM) for the evaluation of the crystals’ morphology and their approximate size and through thermal analysis using the thermogravimetric (TG) method and differential scanning calorimetry (DSC). The results obtained confirm the inclusion of tenoxicam in the cyclodextrin cavity.