Romanian Society of Pharmaceutical Sciences
 

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STUDIES ON THE ANTIMYCOBACTERIAL ACTION OF A NOVEL COMPOUND OF THE THIADIAZOLE CLASS, 2-(PROPYL-THIO)-5H-[1,3,4]-THIADIAZOLE[2,3-B]-QUINAZOLINE-5-ONE

SERGHEI POGREBNOI 1#, CORNEL CHIRIŢĂ 2#*, VLADIMIR VALICA 5#, FLIUR MACAEV 1#, MARIANA CARMEN CHIFIRIUC 3,4#, CRINA KAMERZAN 4#, LIVIA UNCU 5#, ANDREI UNCU 6#, SIMONA NEGREŞ 2#, FLORIANA ELVIRA IONICĂ 7#, FLORICA NICOLESCU 8#, ILINCA-MIHAELA MARANDIUC 9#, EMIL ŞTEFĂNESCU 2#

1.Chemistry Institute of the Academy of Sciences of Moldova, 3 Academy Street, MD 2028, Chişinău, Moldova
2 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmacology and Clinical Pharmacy Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
3 .University of Bucharest, Faculty of Biology, Botany and Microbiology Department, 1-3 Portocalelor Street, 060101, Bucharest, Romania
4 .Research Institute of the Bucharest University, 36-46 Mihail Kogălniceanu Boulevard., 050107, Bucharest, Romania
5 .“Nicolae Testemiţanu” State University for Medicine and Pharmacy, Scientific Medicines Centre, 66 Mălina Mică Street, MD 2025, Chişinău, Moldova
6 .“Nicolae Testemiţanu” State University for Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Chemistry and Toxicology Department, 66 Mălina Mică Street, MD 2025, Chişinău, Moldova
7 .Craiova University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Assistance and Communication with the Patient Department, 2 Petru Rareş Street, 200349, Craiova, Romania
8 .“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Toxicology Department, 6 TraianVuia Street, 020956, Bucharest, Romania
9 .Bioplus Pharmacy, 2 Mihail Sebastian Street, 050784, Bucharest, Romania

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The aim of the current study was the antimicrobial screening of a newly synthesised thiadiazolic compound, 2-(propylthio)-5H-[1,3,4]-thiadiazole[2,3-b]-quinazoline-5-one. The study was conducted for the qualitative and quantitative assessment of the antimicrobial activity, as well as its influence on the adherence capacity inhibition of certain microbial strains. Antimicrobial activity has been approached by means of instrumental techniques, such as flow cytometry. The results of this study have demonstrated the effect of the newly synthesised compound against Gram-negative bacteria through the permeabilization of the bacterial cell wall and against Gram-positive bacteria through the inhibition of the efflux pumps activity.