Romanian Society of Pharmaceutical Sciences

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SPECTRAL CHARACTERIZATION OF NEW 2-((4- ETHYLPHENOXY)METHYL)-N- (ARYLCARBAMOTHIOYL)BENZAMIDES

MIRON TEODOR CĂPROIU1, CARMEN LIMBAN2, ALEXANDRU VASILE MISSIR2, DIANA CAMELIA NUŢĂ2*, LAURENȚIU MORUȘCIAG2

1.Romanian Academy, Organic Chemistry Center “Costin D. Nenitzescu” 202B Splaiul Independentei, 060023, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Chemistry Department, 6 Traian Vuia Str., 020956, Bucharest, Romania

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We report here the characterization of the new synthesized thiourea derivatives by IR, 1H-NMR, 13C-NMR and elemental analysis. In the FTIR (Fourier transform infrared) spectrum the new compounds were characterized by NH, C=N, C=S, C–H of the methyl and methylene groups, and alkyl- arylether stretching vibrations. The 1H-NMR spectrum in dmso-d6 confirmed the proposal structures showing the presence of the NH group, ethyl group, and methylene group attached to the oxygen and aromatic protons. The 13C-NMR spectrum has a singlet signal due to the C=S group, C16 being the most deshielded carbon. The new compounds were synthesized in order to evaluate the influence of fabricated nanomaterials on the biofilm development. The results could be of a great interest for the biomedical field and open new directions for the design of film- coated surfaces with antibiofilm properties.