Romanian Society of Pharmaceutical Sciences

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RELEASE STUDIES OF CEFOTAXIME SODIUM SALT FROM COATED ION EXCHANGE RESIN MICROPARTICLES

ȘTEFANIA RACOVIȚĂ 1, ION BUNIA 1, IOAN PLEȘCA 1, SILVIA VASILIU 1, LENUȚA PROFIRE 2, LILIANA FOIA 2*, VASILICA TOMA 2

1.“Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487, Iași, Romania
2.“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iași, Romania
*corresponding author: [email protected]

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Microparticles based on acrylic ion exchange resin and ion exchange resins coated with two microbial exopolysaccharides (xanthan and gellan) have been used as carriers for cefotaxime sodium salt delivery. The coated and uncoated ion exchange resin microparticles were loaded with the drug by a diffusion process. The release kinetics of the drug was studied by elution with solutions at different pH values. The analysis of the in vitro release data was performed using different mathematical models such as: Boyd, Higuchi, Korsmeyer-Peppas and Baker-Lonsdale models. The kinetic data of the release process indicates that the deliverance mechanism of cefotaxime from coated and uncoated ion exchange resin microparticles was controlled by swelling and diffusion processes. Also, the bactericidal potential of cefotaxime released from coated and uncoated microparticles was highlighted by antimicrobial tests.