Romanian Society of Pharmaceutical Sciences
 

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REDOX STATUS IN WISTAR RAT BLOOD AFTER HYPOXIA

MIHAI LIVIA GRAŢIELA1*, MITREA NICULINA2, PAPACOCEA RALUCA1, CIORNEI CĂTĂLINA1, BĂDĂRĂU ANCA1

1University of Medicine and Pharmacy “Carol Davila “, Faculty of Medicine, Departemnt of Physiology I, Bucharest, Romania.
2 University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Biochemistry, Bucharest, Romania.

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The regulation of tissue oxygen homeostasis is a fundamental and a defence parameter during hypoxia and represents a basic problem of the physical effort, life at altitude adaptation and neonatological pathology. The integration of the circulation and breathing mechanisms are already known, but the integrative mechanisms which regulate and control the amount of hemoglobin and the response to oxidative aggression are less clarified. In the present study we monitorized the blood antioxidant parameters in immature Wistar rats exposed to hypoxia. We measured the activity of the antioxidant enzymes (catalase - CAT, superoxide dismutase -SOD, glutahion peroxidase - GPx) and also transaminases (ALT, AST) and lactate dehidrogenase (LDH) as markers of cellular destruction.