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PREVENTING CARDIAC COMPLICATIONS AFTER NON-CARDIAC NON-VASCULAR SURGERY BY USING PERIOPERATIVE STATIN THERAPY – A PROSPECTIVE STUDY IN CONSTANTA COUNTY, ROMANIA

IRINEL-RALUCA PAREPA ^1#*, ANDRA-IULIA SUCEVEANU ^1#, LAURA MAZILU ^1#, AQEL MOHAMED ^2#, DANIEL NIŢĂ ^2#, LILIANA-ANA TUŢĂ ^1#

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The aim of the study was to evaluate if statins reduce the risk of cardiac events when given during perioperative period in patients who undergo non-cardiac, non-vascular surgery. 1,380 “statin-naive” patients with no evidence of cardiac disease were randomised for: rosuvastatin 10 mg/day (n = 691), and placebo (n = 689), given 10 days before and 20 days after surgery and were followed-up 3 months after surgery. Endpoint was defined as new-onset angina, silent cardiac ischemia, non-fatal acute coronary syndrome or fatal coronary heart disease. 82 patients (5.95%) suffered cardiac events during follow-up: 31 from statin arm and 51 from placebo arm (p = 0.0029). After adjusting for variables, the statin arm had a relative-risk reduction of 39% (p = 0.0189) for cardiac events. No significant decrease in LDL-cholesterol was found in statin patients (p = 0.5664). Perioperative statin therapy was protective against cardiac complications of non-cardiac non-vascular surgery, irrespective of its lipid-lowering effect.